Acenac Tablets Usage And SafetyDosageAceclofenacSide EffectsCommon ( may affect up to 1 in 10 people): ? dizziness ? nausea (feeling sick) ? diarrhoea ? increased liver enzymes in the bloodUncommon ( may affect up to 1 in 100 people): ? wind ? inflammation or irritation of the lining of the stomach ? constipation ? vomiting ? mouth ulcers ? itching ? rash ? inflammation of the skin . Rare ( may affect up to 1 in 1,000 people): ? hypersensitivity (allergic reaction) ? problems with eyesight ? heart failure ? high blood pressure shortness of breath ? bleeding from the stomach or bowel ? stomach or bowel ulceration Drug InteractionsSelective serotonin-reuptake inhibitors (SSRIs) such as citalopram, escitalopram, fluoxetine, fluvoxamine, paroxetine and sertraline) or manic depression (lithium) , cardiac glycosides such as digoxin , (antihypertensives: ACE inhibitors such as enalopril, lisinopril; angiotensin II receptor antagonists such as losartan, candesartan; also hydralazine, methyldopa, clonidine, moxonidine, propranalol) , quinolone antibiotics such as ciprofloxacin, ofloxacin, levofloxacin , moxifloxacin , thiazides,furosemide amiloride hydrochloride , warfarin, heparin , methotrexate , mifepristone , (glucocorticoids such as hydrocortisone,prednisolone,) ciclosporin or tacrolimus , glibenclamide, glicazide, tolbutamide , clopidogrel.IndicationAceclofenac is used to relieve pain and reduce redness and swelling (inflammation) in patients suffering from: ? Arthritis of the joints (osteoarthritis). This commonly occurs in patients over the age of 50 and causes the loss of the cartilage and bone tissue next to the joint. ? Autoimmune disease that causes chronic inflammation of the joints (rheumatoid arthritis). ? Arthritis of the spine which can lead to the fusion of the vertebrae (ankylosing spondylitis).When not to UseDo not take Aceclofenac : ? If you are allergic to aceclofenac or any of the other ingredients of this medicine , if you areallergic to aspirin or any other NSAIDs (such as ibuprofen, naproxen or diclofenac).? If you have taken aspirin or any other NSAIDs and experienced one of the following:- Asthma attack causing tightness in the chest wheezing and difficulty breathing.- Runny nose, itching and/or sneezing (irritation of the nose).- Raised red circular patchy rash on the skin which may have felt itchy or like a sting or burn .- A severe allergic reaction known as anaphylactic shock. The symptoms may be life threatening and include difficulty breathing, wheezing, abdominal pain and vomiting .