Anplag Tablets 90Mg (1 Strip = 10 Tablets)

Anplag Tablets Usage And Safety
Dosage

Ticagrelor

Side Effects

Neoplasms benign, malignant and unspecified (including cysts and polyps): Uncommon: Tumour bleedings, Blood and lymphatic system disorders: Very common: Blood disorder bleedings, Immune system disorders: Uncommon: Hypersensitivity including angioedemac, Metabolism and nutrition disorders: Very common: Hyperuricaemiad ; Common: Gout/Gouty Arthritis, Psychiatric disorders : Uncommon: ConfusionNervous system disorders : Common: Dizziness, Syncope, Headache ; Uncommon: Intracranial haemorrhage, Eye disorders : Uncommon: Eye haemorrhagee, Ear and labyrinth disorders : Common: Vertigo; Uncommon: Ear haemorrhageVascular disorders : Common: HypotensionRespiratory, thoracic and mediastinal disorders : Very common: Dyspnoea ; Common: Respiratory system bleedings.

Drug Interactions

Strong CYP3A Inhibitors : Strong CYP3A inhibitors substantially increase ticagrelor exposure and so increase the risk ofdyspnea, bleeding, and other adverse events. Avoid use of strong inhibitors of CYP3A (e.g.,ketoconazole, itraconazole, voriconazole, clarithromycin, nefazodone, ritonavir, saquinavir, nelfinavir, indinavir, atazanavir and telithromycin).Strong CYP3A Inducers : Strong CYP3A inducers substantially reduce ticagrelor exposure and so decrease the efficacy of ticagrelor. Avoid use with strong inducers of CYP3A (e.g., rifampin, phenytoin, carbamazepine and phenobarbital).Aspirin : Use of Ticagrelor with aspirin maintenance doses above 100 mg reduced the effectiveness of ticagrelor.Simvastatin, Lovastatin : Ticagrelor increases serum concentrations of simvastatin and lovastatin because these drugs are metabolized by CYP3A4. Avoid simvastatin and lovastatin doses greater than 40 mg.Digoxin : Ticagrelor inhibits the P-glycoprotein transporter; monitor digoxin levels with initiation of or change in Ticagrelor therapy.

Indication

Ticagrelor is indicated to reduce the rate of:? Cardiovascular death? Myocardial infarction? Stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI)? Also reduces the rate of stent thrombosis in patients who have been stented for treatment of ACS

When not to Use

History of Intracranial Hemorrhage : Ticagrelor is contraindicated in patients with a history of intracranial hemorrhage (ICH) because of a high risk of recurrent ICH in this population.Active Bleeding : Ticagrelor is contraindicated in patients with active pathological bleeding such as peptic ulcer or intracranial hemorrhage.Hypersensitivity : Ticagrelor is contraindicated in patients with hypersensitivity (e.g., angioedema) to ticagrelor or : any component of the product.Severe Hepatic Impairment : Ticagrelor is contraindicated in patients with severe hepatic patients because of probable increase in exposure. Severe hepatic impairment increases the risk of bleeding because of reduced synthesis of coagulation proteins.