Berica Tablets Usage And SafetyDosageEtoricoxibSide EffectsCommon : Alveolar osteitis, edema/fluid retention, dizziness, headache, palpitations, arrhythmia, hypertension, bronchospasm, constipation, flatulence, gastritis, acid reflux, diarrhea, dyspepsia, epigastric discomfort, nausea, vomiting, ALT increased, AST increased, ecchymosis, asthenia/fatigue and flu-like disease.Uncommon : Gastroenteritis, upper respiratory infection, urinary tract infection, anemia, leukopenia, thrombocytopenia, hypersensitivity, increase or decrease appetite,weight gain, anxiety, depression, mental acuity decreased, hallucinations, dysgeusia, insomnia, paresthaesia/hypaesthesia, somnolence, blurred vision, conjunctivitis, tinnitus, vertigo, atrial fibrillation, tachycardia, congestive heart failure, non-specific ECG changes, angina pectoris, myocardial infarction, flushing, cerebrovascular accident, transient ischemic attack, hypertensive crisis, vasculitis, cough, dyspnea, epistaxis, abdominal distention, bowel movement pattern change, constipation, dry mouth, gastroduodenal ulcer, peptic ulcer, irritable bowel syndrome, pancreatitis, facial edema, pruritus, rash, erythema, urticaria, muscular cramp/spasm, musculoskeletal pain/stiffness,proteinuria, serum creatinine increased, renal failure/renal insufficiency, chest pain, blood urea nitrogen increased, creatine phosphokinase increased, hyperkalemia and uric acid increased.Rare : Angioedema/anaphylactic/anaphylactoid reactions including shock, confusion, restlessness, hepatitis, hepatic failure, jaundice, Stevens-Johnson syndrome, toxic epidermal necrolysis, fixed drug eruption and blood sodium decreased.Drug InteractionsOral anticoagulants , Diuretics, ACE inhibitors and Angiotensin II antagonists , Acetylsalicylic Acid , Ciclosporin and Tacrolimus , Lithium , Methotrexate , Oral contraceptives , Hormone Replacement Therapy (HRT) , Digoxin , Sulfotransferases , Rifampicin.IndicationEtoricoxib is indicated for:- Symptomatic relief of osteoarthritis (OA) and rheumatoid arthritis (RA)- The management of ankylosing spondylitis (AS)- Treatment of acute gouty arthritis- Relief of acute pain – Relief of chronic musculoskeletal pain- Treatment of primary dysmenorrhea- Treatment of moderate to severe acute post-operative pain associated with dental surgery- Treatment of moderate to severe acute post-operative pain associated with abdominal gynecological surgery .When not to UseEtoricoxib is contraindicated in:- Hypersensitivity to active substance or to any of the excipient of the product.- Active peptic ulceration or active gastrointestinal (GI) bleeding.- Patients who have experienced bronchospasm, acute rhinitis, nasal polyps, angioneurotic edema, urticaria or allergic-type reactions after taking acetylsalicylic acid or NSAIDs including COX-2 (cyclooxygenase-2) inhibitors.- Severe hepatic dysfunction (serum albumin <25 g/L or Child-Pugh score = 10).- Estimated renal creatinine clearance < 30mL/min.- Children and adolescents under 16 years of age.- Inflammatory bowel disease.- Congestive heart failure (NYHA II-IV).- Patients with hypertension whose blood pressure is persistently elevated above 140/90mmHg and has not been adequately controlled.- Established ischemic heart disease, peripheral arterial disease and/or cerebrovascular disease.
