-7%

Donecept Tablets 10Mg (1 Box = 1 Strip)(1 Strip = 10 Tablets)

Original price was: Rs.420.0.Current price is: Rs.390.6.

Per Box

SKU: DONTAB921 Categories: Brain & Nerve Health, Medicines, Memory Loss & Alzheimer Brand: Atco Laboratories Limited

Specifications

Donecept Tablets Specification
Requires Prescription (YES/NO)

Generics

Donepezil HCl

Used For

Dementia

How it works

Donepezil hydrochloride is a specific and reversible inhibitor of acetylcholinesterase, the predominant cholinesterase in the brain. Donepezil hydrochloride is in vitro over 1000 times more potent an inhibitor of this enzyme than of butyrylcholinesterase, an enzyme that is present mainly outside the central nervous system.

Usage & Safety

Donecept Tablets Usage And Safety
Dosage

Donepezil HCl

Side Effects

Infections and Infestations: Common: common cold. Metabolism and nutrition disorders: Common: anorexia. Psychiatric disorders: Common: hallucinations, agitation, aggressive behavior and Abnormal dreams and Nightmares (Reports of hallucinations, abnormal dreams, nightmares, agitation and aggressive behavior have resolved on dose-reduction or discontinuation of treatment). Nervous system disorders: Common: syncope, dizziness and insomnia.Uncommon: seizure. Rare: extrapyramidal symptoms. Very rare: Neuroleptic malignant syndrome Cardiac disorders: Uncommon: bradycardia. Rare: sino-atrial block, atrioventricular block. Gastrointestinal disorders: very common: diarrhea and nausea. Common: Vomiting, abdominal disturbance. Uncommon: gastrointestinal hemorrhage, Gastric and duodenal ulcers. Hepato-biliary disorders: Rare: liver dysfunction including hepatitis (in case of unexplained liver dysfunction, withdrawal of Donepezil should be considered). Skin and subcutaneous tissue disorders: Common: rash and pruritis. Musculoskeletal, connective tissue and bone disorders: Common: muscle cramps Renal and urinary disorders: Common: urinary incontinence. General disorders and administration site conditions: Very common: headache. Common: fatigue and pain .

Drug Interactions

Theophylline, warfarin, cimetidine or digoxin , ketoconazole and quinidine, CYP3A4 inhibitors, such as itraconazole and erythromycin, and CYP2D6 inhibitors, such as fluoxetine , Enzyme inducers, such as rifampicin, phenytoin, carbamazepine and alcohol .

Indication

It is indicated for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.

When not to Use

It is contraindicated in patients with a known hypersensitivity to donepezil hydrochloride, piperidine derivatives, or to any excipients used in the formulation.

Precautions

Donecept Tablets Precautions
Precaution

Because of their pharmacological action, cholinesterase inhibitors may have vagotonic effects on heart rate (e.g., bradycardia). The potential for this action may be particularly important to patients with sick sinus syndrome or other supraventricular cardiac conduction conditions, such as sinoatrial or atrioventricular block. There have been reports of syncope and seizures. In investigating such patients the possibility of heart block or long sinusal pauses should be considered.

Warnings

Donecept Tablets Warnings
Warning 1

Patients at increased risk for developing ulcers, e.g., those with a history of ulcer disease or those receiving concurrent nonsteroidal anti-inflammatory drugs (NSAIDs), should be monitored for symptoms.

Warning 2

Donepezil Hydrochloride, as a cholinesterase inhibitor, is likely to exaggerate succinylcholine-type muscle relaxation during anaesthesia .

Warning 3

This medicinal product contains lactose. Patients with rare hereditary problems of galactose intolerance, the Lapp lactase deficiency or glucose-galactose malabsorption should not take this medicine.

Additional Info

Donecept Tablets Additional Information
Pregnancy category

Always consult your physician before using any medicine.

Storage (YES/NO)

Store this medicine at room temperature, away from direct light and heat.

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