Donecept Tablets Usage And Safety
Dosage
Donepezil HCl
Side Effects
Infections and Infestations: Common: common cold. Metabolism and nutrition disorders: Common: anorexia. Psychiatric disorders: Common: hallucinations, agitation, aggressive behavior and Abnormal dreams and Nightmares (Reports of hallucinations, abnormal dreams, nightmares, agitation and aggressive behavior have resolved on dose-reduction or discontinuation of treatment). Nervous system disorders: Common: syncope, dizziness and insomnia.Uncommon: seizure. Rare: extrapyramidal symptoms. Very rare: Neuroleptic malignant syndrome Cardiac disorders: Uncommon: bradycardia. Rare: sino-atrial block, atrioventricular block. Gastrointestinal disorders: very common: diarrhea and nausea. Common: Vomiting, abdominal disturbance. Uncommon: gastrointestinal hemorrhage, Gastric and duodenal ulcers. Hepato-biliary disorders: Rare: liver dysfunction including hepatitis (in case of unexplained liver dysfunction, withdrawal of Donepezil should be considered). Skin and subcutaneous tissue disorders: Common: rash and pruritis. Musculoskeletal, connective tissue and bone disorders: Common: muscle cramps Renal and urinary disorders: Common: urinary incontinence. General disorders and administration site conditions: Very common: headache. Common: fatigue and pain .
Drug Interactions
Theophylline, warfarin, cimetidine or digoxin , ketoconazole and quinidine, CYP3A4 inhibitors, such as itraconazole and erythromycin, and CYP2D6 inhibitors, such as fluoxetine , Enzyme inducers, such as rifampicin, phenytoin, carbamazepine and alcohol .
Indication
It is indicated for the symptomatic treatment of mild to moderately severe Alzheimer’s dementia.
When not to Use
It is contraindicated in patients with a known hypersensitivity to donepezil hydrochloride, piperidine derivatives, or to any excipients used in the formulation.