K-1000 Chewable Usage And Safety
Dosage
Calcium , Vitamin D , Vitamin K2
Side Effects
Common: Constipation or stomach upset may occur. Uncommon: Hypercalcemia/hypercalciuria, Nausea/vomiting, loss of appetite, unusual weight loss, mental/mood changes, change in the amount of urine, bone/muscle pain, headache, increased thirst, increased urination, weakness, tiredness, fast/pounding heartbeat. Rare: Serious allergic reaction, including: rash, itching/swelling (especially of the face/tongue/throat), severe dizziness, trouble breathing .
Drug Interactions
Calcium can decrease the absorption of other drugs such as tetracycline antibiotics (e.g., doxycycline, minocycline), bisphosphonates (e.g., alendronate), estramustine, levothyroxine, and quinolone antibiotics (e.g., ciprofloxacin, levofloxacin). There should be a gap of at least 4 hours when taking these drugs with K-1000. Certain medications can decrease the absorption of Vitamin D3 (bile acid sequestrants such as cholestyramine/colestipol, mineral oil, orlistat). There should be a gap of at least 4 hours when taking these drugs with K-1000. Patients co-treated with cardiac glycosides along with cholecalciferol may be susceptible to high calcium levels and should have ECG parameters and calcium levels monitored. It is recommended to reduce the dose or interrupt treatment if the calcium content in the urine exceeds 7.5 mmol/24 hours (300 mg/24 hours). Simultaneous administration of benzothiadiazine derivatives (thiazide diuretics increases the risk of hypercalcaemia because they decrease the calcium excretion in the urine. The calcium levels in plasma and urine should therefore be monitored for patients undergoing long-term treatment with calcium/Vitamin D3 supplementation.
Indication
K-1000 chewable tablets are used to prevent conditions related to calcium and Vitamin D3 deficiency such as: a) Osteoporosis b) Osteomalacia c) Hypoparathyroidism d) Musculoskeletal pain . K-1000 chewable tablets are also used to overcome calcium and Vitamin D3 deficiencies in certain populations and disease states such as:a) Postmenopausal women b) Bone recovery after fractures . K-1000 chewable tablets may also be used to prevent or treat bone-related disorders such as osteoporosis in people taking certain medication.
When not to Use
K-1000 must not be used in patients with: Hypersensitivity to any of the active substances (Vitamin D3 or its analogues, calcium or Vitamin K2 or its analogues). Due to calcium / cholecalciferol components, K-1000 tablets must not be used in: Hypercalcaemia and/or hypercalciuria Nephrolithiasis (Renal calculi) Hypervitaminosis D Severe renal impairment Metastatic calcification .