Lefora Tablets Usage And SafetyDosageLeflunomideSide EffectsCommon side effects (may affect up to 1 in 10 people) : A slight decrease in the number of white blood cells (leucopenia), – mild allergic reactions, – loss of appetite, weight loss (usually insignificant), – tiredness (asthenia), – headache, dizziness, – abnormal skin sensations like tingling (paraesthesia), – mild increase in blood pressure, – colitis, – diarrhoea, – nausea, vomiting, – inflammation of the mouth or mouth ulcers, – abdominal pain. Uncommon side effects (may affect up to 1 in 100 people) : A decrease in the number of red blood cells (anaemia) and a decrease in the number of blood platelets (thrombocytopenia), – a decrease in the levels of potassium in the blood, – anxiety, – taste disturbances, – urticaria (nettle rash), – tendon rupture, – an increase in the levels of fat in the blood (cholesterol and triglycerides), – a decrease in the levels of phosphate in the blood.Rare side effects (may affect up to 1 in 1,000 people) : An increase in the numbers of blood cells called eosinophiles (eosinophilia); mild decrease in the number of white blood cells (leucopenia); decrease in the number of all blood cells (pancytopenia), – severe increase in blood pressure, – inflammation of the lung (interstitial lung disease), – an increase in some liver results which may develop into serious conditions such as hepatitis and jaundice.Drug InteractionsChloroquine and hydroxychloroquine, intramuscular or oral gold, D-penicillamine, azathioprine and other immunosuppressive medicines (e.g. methotrexate ) , warfarin , teriflunomide , repaglinide, pioglitazone, nateglinide, or rosiglitazone , daunorubicin, doxorubicin, paclitaxel, or topotecan , duloxetine , alosetron , theophylline , tizanidine , oral contraceptives (containing ethinylestradiol and levonorgestrel) , cefaclor, benzylpenicillin , indomethacin, ketoprofen , furosemide , zidovudine , rosuvastatin, simvastatin, atorvastatin, pravastatin , sulfasalazine.IndicationIt is used to treat adult patients with active rheumatoid arthritis or with active psoriatic arthritis.When not to UseDo not take leflunomide : – If you have ever had an allergic reaction to leflunomide (especially a serious skin reaction, often accompanied by fever, joint pain, red skin stains, or blisters e.g. Stevens-Johnson syndrome)or to any of the other ingredients of this medicine , or if you are allergic to teriflunomide (used to treat multiple sclerosis),- If you have any liver problems,- If you have moderate to severe kidney problems .