Lezra Tablets Usage And Safety
Dosage
Letrozole
Side Effects
Common or very common: Abdominal pain ,alopecia ,anorexia,appetite increase, arthralgia,bone fracture, Constipation, depression, diarrhea, dizziness, dry skin, dyspepsia, fatigue, headache, hot flushes, hypercholesterolaemia, hypertension, increased sweating, musculoskeletal pain, nausea, osteoporosis, peripheral oedema, rash, vaginal bleeding,vomiting, weight changes. Uncommon: Anxiety, arthritis, blurred vision, breast pain, cardiac events, cataract, cerebrovascular events, cough, Dysaesthesia, dyspnea, eye irritation, general oedema, insomnia, leucopenia, memory impairment, mucosal Dryness, palpitation, pruritus, pyrexia, stomatitis, tachycardia, taste disturbance, thrombophlebitis, tumour pain, urinary frequency,urinary-tract infection,urticaria. vaginal discharge. Rare: Arterial thrombosis . pulmonary embolism. Frequency not known: Hepatitis ,toxic epidermal necrolysis.
Drug Interactions
Tamoxifen , Cimetidine , Warfarin .
Indication
It is indicated in : ? First-line treatment in postmenopausal women with hormone-dependent advanced breast cancer.? Adjuvant treatment of oestrogen receptor positive invasive early breast cancer in postmenopausal women.? Advanced breast cancer in postmenopausal women (naturally or artificially induced menopause) in whom other antiestrogen therapy has failed.? Extended adjuvant treatment of hormone-dependent invasive breast cancer in postmenopausal women who have received standard adjuvant tamoxifen therapy for 5 years.? Neo adjuvant treatment in postmenopausal women with localized hormone receptor positive, human epidermal growth factor-2 negative breast cancer where chemotherapy is not suitable and surgery not yet indicated.
When not to Use
Known hypersensitivity to the active substance, or to any of the excipients. Not indicated for premenopausal women. Letrozole is contraindicated during breast-feeding. Letrozole is contraindicated during pregnancy. Letrozole can cause fetal harm.
