Onseron 25Ml Usage And Safety
Dosage
Ondansetron
Side Effects
Adverse reactions observed when ondansetron is used for Chemotherapy induced Nausea and Vomiting Diarrhea, Headache, Fever, Constipation, Rash.Cardiovascular:Rare cases of angina (chest pain), electrocardiographic alterations, hypotension, and tachycardia, QT prolongation, ST segment depression, bradycardia.Hepatic: In comparative trials in cisplatin chemotherapy patients with normal baseline values of aspartate transaminase (AST) and alanine transaminase (ALT), these enzymes have been reported to exceed twice the upper limit of normal in approximately 5% of patients. The increases were transient and did not appear to be related to dose or duration of therapy. On repeat exposure, similar transient elevations in transaminase values occurred in some courses, but symptomatic hepatic disease did not occur.Neurological: There have been rare reports consistent with, but not diagnostic of, extrapyramidal reactions in patients receiving ondansetron Injection and rare cases of grand mal seizure.Other:Rare cases of hypokalemia.Adverse reactions observed when ondansetron is used for Postoperative Nausea and Vomiting Headache, Drowsiness/sedation, Injection site reaction, Fever, Cold sensation, Pruritus and Paresthesia.OTHER ADVERSE REACTIONS:Local reactions:Pain, redness, burning at site of injectionLower respiratory: HiccupsSkin:Urticaria, Stenvens-Johnson syndrome, toxic epidermal necrolysis.Eye disorders:Transient blindnessNeurological:Oculogyric crisis, appearing alone,as well as with other dystonic reactions.Transient dizziness during or shortly after intervenous administration.
Drug Interactions
Drugs Affecting Cytochrome P-450 Enzymes , Apomorphine , Phenytoin, Carbamazepine, and Rifampin , Tramadol , Serotonergic Drugs , carmustine, etoposide, and cisplatin , Temazepam , Alfentanil and Atracurium.
Indication
Prevention of Nausea and Vomiting Associated with Initial and Repeat Courses of Emetogenic Cancer Chemotherapy.
When not to Use
Ondansetron is contraindicated for patients known to have hypersensitivity (e.g., anaphylaxis) to this product or any of its components. Anaphylactic reactions may be observed in patients taking ondansetron.The concomitant use of apomorphine with ondansetron is contraindicated based on reports of profound hypotension and loss of consciousness when apomorphine was administered with ondansetron.
