Rifaxa Tablets Usage And SafetyDosageRifaximinSide EffectsTraveler?s Diarrhea : Common : Flatulence, headache, abdominal pain, rectal tenesmus, defecation urgency, nausea, constipation, pyrexia, vomiting. Uncommon : Lymphocytosis, monocytosis, neutropenia, ear pain, motion sickness, tinnitus, abdominal distension, diarrhea, dry throat, fecal abnormality, gingival disorder, inguinal hernia, dry lips, stomach discomfort, chest pain, fatigue, malaise, pain, weakness, dysentery, respiratory tract infection, upper respiratory tract infection, sunburn, aspartate aminotransferase increased, blood in stool, blood in urine, weight decreased, anorexia, dehydration, arthralgia, muscle spasms, myalgia, neck pain, abnormal dreams, dizziness, migraine, syncope, loss of taste, insomnia, choluria, dysuria, hematuria, polyuria, proteinuria, urinary frequency, dyspnea, nasal passage irritation, nasopharyngitis, pharyngitis, pharyngolaryngeal pain, rhinitis, rhinorrhea, clamminess, rash, sweating increased, hot flashes.Hepatic Encephalopathy : Common : Peripheral edema, nausea, dizziness, fatigue, ascites, muscle spasms, pruritus, abdominal pain, abdominal distension, anemia, cough, depression, insomnia, nasopharyngitis, upper abdominal pain, arthralgia, back pain, constipation, dyspnea, pyrexia, rash. Uncommon : Vertigo, lower abdominal pain, abdominal tenderness, dry mouth, esophageal variceal bleed, stomach discomfort, chest pain, generalized edema, influenza like illness, pain, cellulitis, pneumonia, rhinitis, upper respiratory tract infection, confusion, fall, procedural pain, weight increased, anorexia, dehydration, hyperglycemia, hyperkalemia, hypoglycemia, hyponatremia, myalgia, pain in extremity, amnesia, disturbance in attention, hypoesthesia, memory impairment, tremor, confusional state, epistaxis, hypotension.Drug InteractionsCYP3A4 substrates , rifamycins , substrate of P-glycoprotein.IndicationTo reduce the development of drug-resistant bacteria and maintain the effectiveness of Rifaximin and other antibacterial drugs, Rifaximin when used to treat infection should be used only to treat or prevent infections that are proven or strongly suspected to be caused by susceptible bacteria.When not to UseRifaximin is contraindicated: – In patients with a hypersensitivity to rifaximin, any of the rifamycin antimicrobial agents, or any of the excipient of product. -During pregnancy and in women of childbearing potential not using contraception. – In -the treatment of traveler?s diarrhea caused by invas ive enteric pathogens such as Campylobacter, Salmonella and Shighella, which typically produce dysentery-like diarrhea characterized by fever , blood in the stool and high stool frequency.
