Glucovance Tablets Usage And Safety
Dosage
Glibenclamide , Metformin HCl
Side Effects
Diarrhoea, Headache, Nausea / Vomiting, Abdominal pain and Dizziness.
Drug Interactions
When the drugs like the thiazides and other diuretics, corticosteroids, phenothiazines, thyroid products, estrogens, oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium channel blocking drugs, and isoniazid are administered to a patient receiving this medicine , the patient should be closely observed for loss of blood glucose control. When such drugs are withdrawn from a patient receiving this medicine, the patient should be observed closely for hypoglycemia. Metformin HCl is negligibly bound to plasma proteins and is, therefore, less likely to interact with highly protein-bound drugs such as salicylates, sulfonamides, chloramphenicol, and probenecid as compared to sulfonylureas, which are extensively bound to serum proteins.
Indication
It is indicated as initial therapy, as an adjunct to diet and exercise, to improve glycemic control in patients with type 2 diabetes whose hyperglycemia cannot be satisfactorily managed with diet and exercise alone. It is indicated as second-line therapy when diet, exercise, and initial treatment with a sulfonylurea or Metformin do not result in adequate glycemic control in patients with type 2 diabetes.
When not to Use
Metformin HCl and Glibenclamide is contraindicated in patients with: Renal disease or renal dysfunction (e.g., as suggested by serum creatinine levels =1.5 mg/dL [males], =1.4 mg/dL [females], or abnormal creatinine clearance) which may also result from conditions such as cardiovascular collapse (shock), acute myocardial infarction, and septicemia. Congestive heart failure requiring pharmacologic treatment. Known hypersensitivity to Metformin Hydrochloride or Glibenclamide. Acute or chronic metabolic acidosis, including diabetic ketoacidosis, with or without coma. Diabetic ketoacidosis should be treated with insulin.
Acefyl Cough Syrup 125Ml