Panadol Cf Usage And SafetyDosageParacetamol , Chlorpheniramine maleate , Pseudoephedrine Hydrochloride Side EffectsParacetamol : Thrombocytopaenia, Anaphylaxis cutaneous hypersensitivity reactions including amoung others skin rashes, angiodema, stevens johnson syndrome, toxic epidermal necrosis, bronchospasm in patients sensitive to aspirin and other NSAIDs, hepatic dysfuction.Psuedoephedrine: Nervousness, Headache, Dizziness, Insomnia, Increased blood pressure, Vomiting, nausea, Mydriasis, acute angle closure glaucoma, most likely to occur in those with closed angle glaucoma Tachycardia, Palpitations Allergic reactions (e.g. rash, urticaria, allergic dermatitis) Dysuria, urinary retention. This is most likely to occur in those with bladder outlet obstruction such as prostatic hypertrophy.Chlorphenamine : Allergic reactions, angioedema, anaphylactic reactions Anorexia, Confusion*, excitation*, irritability*, nightmares*, Disturbance in attention, abnormal coordination, dizziness, headache Sedation, somnolence Blurred vision, Hypotension, Thickening of bronchial, Secretions, Nausea, dry mouth, Vomiting, abdominal pain, diarrhoea, dyspepsia, Exfoliative dermatitis, rash, urticaria, photosensitivity, Muscle twitching, muscle Weakness, Urinary retention, Fatigue, Chest tightness.Drug InteractionsThe anticoagulant effect of warfarin and other coumarins may be enhanced by prolonged regular daily use of paracetamol-containing products with increased risk of bleeding; occasional doses have no significant effect. Concomitant administration of pseudoephedrine hydrochloride-containing products andMAOIs (or within two weeks of stopping of MAOI) may lead to hypertensive crisis. Theanticholinergic effects of chlorphenamine are intensified by MAOIs. Concomitant use of this medication with sympathomimetic agents (such asdecongestants, appetite suppressants and amphetamine-like psychostimulants) which interfere with the catabolism of sympathomimetic amines, may occasionally cause a rise in blood pressure (see Contraindications). Pseudoephedrine-containing products may antagonise the effect of certain classes ofantihypertensives (e.g. beta blockers, methyl-dopa, reserpine, debrisoquine, guanethidine).Concurrent use of chlorphenamine and hypnotics or anxiolytics may potentiatedrowsiness. Concurrent use of alcohol may have a similar effect.Chlorphenamine inhibits phenytoin metabolism and can lead to phenytoin toxicity.IndicationIt is used in : Common cold , Influenza , Fever associated with common cold and flu , Muscle ache, Nasal congestion , Sinus congestion , Headache and sinus pain , Sneezing , Itchy and watery eyes . When not to UseThis product is contraindicated in patients: -With a previous history of hypersensitivity to paracetamol, pseudoephedrine, chlorphenamine, other antihistamines or excipients.- With severe hypertension or severe coronary artery disease.-Who are receiving other sympathomimetics (such as decongestants, appetite suppressants and amphetamine-like psychostimulants).-Who are receiving Monoamine Oxidase Inhibitors (MAOIs), or for two weeks after stopping a MAOI drug.-With severe renal impairment.
